Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050522 | 1.00 | ACE (0.73) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL11049974 | 1.00 | ACE (0.73) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL11049962 | 1.00 | ACE (0.73) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL11050512 | 1.00 | ACE (0.73) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL5175052 | 0.93 | ACE (0.63) | ACEABCB11 | |
| SCHEMBL8280065 | 0.91 | ACE (0.67) | ACEABCB11LMNAPDE3AMEN1 | |
| SCHEMBL11187981 | 0.91 | ACE (0.67) | ACEABCB11LMNAPDE3AMEN1 | |
| Quinapril SCHEMBL4915602 | 0.87 | ACE (0.79) | ACEABCB11LMNAPDE3A | |
| Quinapril SCHEMBL19361887 | 0.85 | ACE (1.00) | ACEABCB11LMNAPDE3ASMN1; SMN2 | |
| Quinapril SCHEMBL678447 | 0.85 | ACE (1.00) | ACEABCB11LMNAPDE3ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4350633-A | ENZYME INHIBITORS, HYPOTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | claimed |
| US-4535168-A | Preparation of indoline-2-carboxylic acid via the intermediate indoline-2-carboxylic acid ester tin complex | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-08-13 | — | — | US | disclosed |
| US-4485241-A | Reduction of indole-2-carboxylic acids to indoline-2-carboxylic acids with lithium, sodium, or potassium in ammonia | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-11-27 | — | — | US | disclosed |