Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 6/20 | 0.35 |
| ▸ | C1R | P00736 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826935 | 0.89 | FFAR1 (0.44) | FFAR1PDE10AAKR1C3AKR1C2PIK3C3 | |
| SCHEMBL828031 | 0.89 | FFAR1 (0.41) | FFAR1PDE10AAKR1C3AKR1C2PIK3C3 | |
| SCHEMBL828030 | 0.89 | FFAR1 (0.41) | FFAR1PDE10AAKR1C3AKR1C2PIK3C3 | |
| SCHEMBL827978 | 0.87 | FFAR1 (0.42) | FFAR1PDE10AAKR1C3AKR1C2PIK3C3 | |
| SCHEMBL826952 | 0.87 | FFAR1 (0.46) | FFAR1PDE10APIK3C3ARC1R | |
| SCHEMBL827287 | 0.86 | FFAR1 (0.43) | FFAR1PDE10APIK3C3ARC1R | |
| SCHEMBL828994 | 0.85 | FFAR1 (0.41) | FFAR1PDE10AAKR1C3AKR1C2PIK3C3 | |
| SCHEMBL828026 | 0.85 | FFAR1 (0.43) | FFAR1PDE10APIK3C3ARC1R | |
| SCHEMBL828396 | 0.85 | FFAR1 (0.41) | FFAR1PDE10APIK3C3ARC1R | |
| SCHEMBL828191 | 0.85 | FFAR1 (0.41) | FFAR1PDE10APIK3C3KITTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143274-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-03-27 | — | — | US | disclosed |