Tiformin

Tiformin

SCHEMBL828055

N=C(N)NCCCC(N)=O

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
CYP1A2 P05177 1/20 0.47
ALB P02768 1/20 0.36
HIF1A Q16665 2/20 0.35
TSHR P16473 1/20 0.35
SPHK1 Q9NYA1 3/20 0.33
PRMT1 Q99873 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33
PAOX Q6QHF9 2/20 0.32
ALDH1A1 P00352 1/20 0.32
ITGB3 P05106 2/20 0.31
ITGA2B P08514 2/20 0.31
CASP2 P42575 1/20 0.31
ADRA1A P35348 1/20 0.31
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tiformin SCHEMBL9772228 0.98 ALOX15 (0.46) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL437938 0.93 SMN1; SMN2 (0.50) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL9772254 0.91 SMN1; SMN2 (0.53) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL9772216 0.91 SMN1; SMN2 (0.53) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL5034174 0.91 SMN1; SMN2 (0.53) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
Hydrochloric Acid SCHEMBL9772261 0.91 ALOX15 (0.48) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL1299189 0.91 SMN1; SMN2 (0.53) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL9772161 0.91 SMN1; SMN2 (0.53) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
SCHEMBL9772204 0.91 SMN1; SMN2 (0.53) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2
Hydrochloric Acid SCHEMBL9632488 0.89 SMN1; SMN2 (0.52) ALOX15MEN1KMT2ASMN1; SMN2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 168 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115551873-A Methods for modulating gastrointestinal microbial metabolic pathways and metabolites 帝斯曼知识产权资产管理有限公司 2022-12-30 CN claimed
CN-114980909-A Cell-free placental treatment for necrotizing enterocolitis 无痛疗法股份有限公司 2022-08-30 CN claimed
CN-108935087-A A kind of breeding method of Rhododendron fortuneilindl. polyploid 浙江农林大学 2018-12-07 CN claimed
CN-108613961-A It is a kind of three-dimensional high sensitivity, the Raman active substrate of anti-friction 山东师范大学 2018-10-02 CN claimed
CN-106086862-A A kind of hydrophobic or oleophobic micron and nanometer composite structure and preparation method thereof 安徽医科大学第附属医院 2016-11-09 CN claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20050208080-A1 Formulation for the administration of medicinal substances HEIGHTMAN NICHOLAS J 2005-09-22 US claimed
EP-1469825-A1 FORMULATION FOR THE ADMINISTRATION OF MEDICINAL SUBSTANCES Heightman, Nicholas John (GB) 2004-10-27 EP claimed
WO-2003061624-A1 FORMULATION FOR THE ADMINISTRATION OF MEDICINAL SUBSTANCES HEIGHTMAN NICHOLAS JOHN (GB) 2003-07-31 WO claimed
EP-0674508-B1 4-GUANIDINOBUTYRAMIDE FOR IMPROVING BLOOD CIRCULATION CEMORC LTD (GB) 1998-06-10 EP claimed
US-5684047-A 4-guanidinobutyramide for improving blood circulation CEMORC LTD (GB) 1997-11-04 US claimed
EP-0674508-A1 4-GUANIDINOBUTYRAMIDE FOR IMPROVING BLOOD CIRCULATION CEMORC LTD. (GB) 1995-10-04 EP claimed
WO-1994013276-A1 4-GUANIDINOBUTYRAMIDE FOR IMPROVING BLOOD CIRCULATION CEMORC LTD. (GB) 1994-06-23 WO claimed
CN-119455003-A Compositions, methods and uses comprising antibody-TLR agonist conjugates AMBRX公司 2025-02-18 CN disclosed
US-4983328-A ANTITUMOR AGENTS BRISTOL-MYERS COMPANY (US) 1991-01-08 US disclosed
US-4518532-A ANTITIMOR ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1985-05-21 US disclosed