Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.68 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.55 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.55 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PRKDC | P78527 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927915 | 0.86 | KMO (0.62) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL13724478 | 0.83 | KMO (0.74) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL303084 | 0.81 | KMO (0.77) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL30634127 | 0.81 | KMO (1.00) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL65857 | 0.81 | KMO (1.00) | KMOPLOD2PLOD3PLOD1MAPT | |
| Hydrochloric Acid SCHEMBL14742166 | 0.80 | KMO (0.74) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL4251811 | 0.80 | KMO (0.74) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL29188572 | 0.80 | ESRRG (0.49) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL4250883 | 0.79 | KMO (0.68) | KMOPLOD2PLOD3PLOD1MAPT | |
| SCHEMBL22209343 | 0.79 | KMO (0.68) | KMOPLOD2PLOD3PLOD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102625799-A | Heterocyclic compounds and their uses | AMGEN INC | 2012-08-01 | — | — | CN | disclosed |
| US-8143274-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-03-27 | — | — | US | disclosed |