Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 11/20 | 0.39 |
| ▸ | BPTF | Q12830 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2743217 | 1.00 | EPHX2 (0.43) | EPHX2KAT2BBPTFALDH1A1AKT1 | |
| SCHEMBL24314234 | 1.00 | EPHX2 (0.43) | EPHX2KAT2BBPTFALDH1A1AKT1 | |
| SCHEMBL799022 | 0.88 | AKT1 (0.39) | EPHX2KAT2BAKT1 | |
| SCHEMBL799377 | 0.88 | AKT1 (0.39) | EPHX2KAT2BAKT1 | |
| SCHEMBL799561 | 0.88 | AKT1 (0.39) | EPHX2KAT2BAKT1 | |
| SCHEMBL18912347 | 0.83 | CA1 (0.53) | KAT2BBPTFCA12CA1CA7 | |
| SCHEMBL8280859 | 0.81 | KAT2B (0.38) | KAT2BBPTF | |
| SCHEMBL26727078 | 0.81 | KAT2B (0.38) | KAT2BBPTFALDH1A1CA12CA1 | |
| SCHEMBL8280865 | 0.81 | KAT2B (0.35) | EPHX2KAT2BBPTFALDH1A1 | |
| SCHEMBL21422792 | 0.79 | EPHX2 (0.42) | EPHX2ALDH1A1AKT1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005080389-A1 | INDAZOLE-CARBOXAMIDE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2005-09-01 | — | — | WO | disclosed |