Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8281642 | 1.00 | MAPT (0.50) | MAPTNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL8280935 | 0.85 | MAPT (0.48) | MAPTKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL8282545 | 0.84 | MAPT (0.47) | MAPTKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL8280938 | 0.83 | MAPT (0.49) | MAPTKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL97043 | 0.72 | NOTUM (0.68) | MAPTNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL5637347 | 0.71 | LSS (0.51) | MAPTNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL14409749 | 0.70 | ESR2 (0.52) | MAPTALDH1A1HPGDPOLBCYP2C9 | |
| SCHEMBL95172 | 0.70 | NOTUM (0.60) | MAPTNOTUMKDM4EALDH1A1HPGD | |
| SCHEMBL1270235 | 0.69 | GCK (0.52) | NR1H4 | |
| SCHEMBL9898682 | 0.69 | GCK (0.52) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005082866-A2 | SUBSTITUTED 1, 2, 4- TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS | PFIZER LIMITED (GB) | 2005-09-09 | — | — | WO | disclosed |