Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16035455 | 0.69 | CNR1 (0.43) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL8283496 | 0.67 | RAB9A (0.48) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL17227734 | 0.66 | KMT2A (0.38) | KMT2AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL23573405 | 0.64 | RAB9A (0.47) | KMT2ANPC1RAB9APKMSMN1; SMN2 | |
| Emorfazone SCHEMBL26203 | 0.62 | BRD4 (0.46) | KMT2ANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2555460 | 0.62 | BRD4 (0.46) | KMT2ANPC1RAB9AALDH1A1PKM | |
| SCHEMBL23573284 | 0.62 | RAB9A (0.42) | KMT2ANPC1RAB9APKMSMN1; SMN2 | |
| SCHEMBL23573483 | 0.62 | MEN1 (0.33) | KMT2ARAB9AMAPTALDH1A1 | |
| SCHEMBL5103228 | 0.61 | ADORA2A (0.44) | KMT2ANPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL18412809 | 0.61 | KMT2A (0.48) | KMT2AMAPTALDH1A1PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077915-A1 | PYRIDAZINONES AS ANTAGONISTS OF A4 INTEGRINS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-25 | — | — | WO | disclosed |