Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arformoterol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 11/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 5/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 5/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.87 |
| ▸ | TSHR | P16473 | 2/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.87 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.87 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.87 |
| ▸ | PGR | P06401 | 1/20 | 0.87 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.87 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.87 |
| ▸ | DRD3 | P35462 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arformoterol SCHEMBL17515075 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Formoterol SCHEMBL29039567 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Arformoterol SCHEMBL4084169 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Arformoterol SCHEMBL31697543 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Formoterol SCHEMBL29369526 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Arformoterol SCHEMBL29488544 | 1.00 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Formoterol SCHEMBL1650339 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Arformoterol SCHEMBL1660800 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Arformoterol SCHEMBL3040814 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 | |
| Formoterol SCHEMBL3670606 | 0.99 | ADRB2 (1.00) | ADRB2ADRB1ADRB3DRD2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2018 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12616654-B2 | Stainless steel can for pressurised metered dose inhalers | CHIESI FARMACEUTICI S.P.A. (IT) | 2026-05-05 | — | — | US | claimed |
| US-12491156-B2 | Carrier particles for dry powder formulations for inhalation | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-12-09 | — | — | US | claimed |
| EP-3701940-B1 | PHARMACEUTICAL COMPOSITION | MEXICHEM FLUOR SA DE CV (MX) | 2025-11-12 | — | — | EP | claimed |
| US-20250312274-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-10-09 | — | — | US | claimed |
| US-20250302742-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | CHIESI FARMACEUTICI S.P.A. (IT) | 2025-10-02 | — | — | US | claimed |
| CN-120037526-A | Pressurized metered dose inhaler comprising buffered pharmaceutical formulation | 奇斯药制品公司 | 2025-05-27 | — | — | CN | claimed |
| EP-4531920-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | Chiesi Farmaceutici S.p.A. (IT) | 2025-04-09 | — | — | EP | claimed |
| EP-4531921-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | Chiesi Farmaceutici S.p.A. (IT) | 2025-04-09 | — | — | EP | claimed |
| EP-4531922-A1 | A PHARMACEUTICAL FORMULATION FOR PRESSURISED METERED DOSE INHALER | Chiesi Farmaceutici S.p.A. (IT) | 2025-04-09 | — | — | EP | claimed |
| CN-119700722-A | Particle size-graded Budigafu inhalation powder spray and preparation method thereof | 山东京卫制药有限公司 | 2025-03-28 | — | — | CN | claimed |
| WO-1999000134-A1 | NEW COMBINATION OF ANTIASTHMA MEDICAMENTS | ASTRA AKTIEBOLAG (PUBL) (SE) | 1999-01-07 | — | — | WO | claimed |
| EP-0871450-A1 | NEW COMBINATION | Astra Aktiebolag (SE) | 1998-10-21 | — | — | EP | claimed |
| CN-1195523-A | Composition | ASTRA AB (SE) | 1998-10-14 | — | — | CN | claimed |
| WO-1998031351-A1 | NEW FORMULATION FOR INHALATION HAVING A POURED BULK DENSITY OF FROM 0.28 TO 0.38 G/ML, COMPRISING FORMOTEROL | ASTRA AKTIEBOLAG (SE) | 1998-07-23 | — | — | WO | claimed |
| WO-1998015280-A1 | NEW COMBINATION | ASTRA AKTIEBOLAG (SE) | 1998-04-16 | — | — | WO | claimed |
| EP-0820276-A1 | PROCESS FOR THE PREPARATION OF RESPIRABLE PARTICLES | Astra Aktiebolag (SE) | 1998-01-28 | — | — | EP | claimed |
| US-5674860-A | ADMINISTERING MEASURED AMOUNTS OF FORMOTEROL(OR ITS SALTS OR SOLVATES) AND BUDESONIDE BY INHALATION | ASTRA AKTIEBOLAG (SE) | 1997-10-07 | — | — | US | claimed |
| US-5637620-A | FINENESS GRAINS; STABILITY; CRYSTAL STRUCTURE; AERODYNAMIC PROPERTIES FOR INHALATION | ASTRA AKTIEBOLAG (SE) | 1997-06-10 | — | — | US | claimed |
| WO-1996032095-A1 | PROCESS FOR THE PREPARATION OF RESPIRABLE PARTICLES | ASTRA AKTIEBOLAG (SE) | 1996-10-17 | — | — | WO | claimed |
| CN-1133004-A | Method for regulating substances | ASTRA AB (SE) | 1996-10-09 | — | — | CN | claimed |