Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 5/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | EIF4E | P06730 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8282816 | 0.85 | GRIA4 (0.53) | GRIA4GRIA2ESR2EIF4EFNTA | |
| SCHEMBL3128599 | 0.81 | GRIA2 (0.47) | GRIA4GRIA2ESR2FFAR1AKR1B1 | |
| SCHEMBL2039846 | 0.76 | ESR2 (0.62) | GRIA4GRIA2ESR2PTPN5FFAR1 | |
| SCHEMBL8282828 | 0.75 | GRIA2 (0.46) | GRIA4GRIA2ALDH1A1 | |
| SCHEMBL3136013 | 0.75 | GRIA4 (0.77) | GRIA4GRIA2FNTAFNTB | |
| SCHEMBL3138584 | 0.75 | GRIA4 (0.65) | GRIA4GRIA2ESR2PTPN5FNTA | |
| SCHEMBL3138108 | 0.74 | GRIA4 (0.66) | GRIA4GRIA2ESR2FNTAFNTB | |
| SCHEMBL5728657 | 0.73 | GRIA4 (0.67) | GRIA4GRIA2ESR2FNTAFNTB | |
| SCHEMBL27969495 | 0.72 | ALAD (0.46) | GRIA4GRIA2ESR2PTPN5FFAR1 | |
| Benzoic Acid SCHEMBL8919114 | 0.72 | ESR2 (0.58) | GRIA4GRIA2ESR2PTPN5FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642361-B2 | Thiophene and furan compounds | ELI LILLY AND COMPANY (US) | 2010-01-05 | — | — | US | disclosed |
| US-20070105852-A1 | Thiophene and furan compounds | ELI LILLY AND COMPANY | 2007-05-10 | — | — | US | disclosed |
| WO-2005070916-A1 | THIOPHENE AND FURAN COMPOUNDS | ELI LILLY AND COMPANY (US) | 2005-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105852-A1 | Thiophene and furan compounds | PSEN2, PSEN1, TPMT | GRIA4 15/4885GRIA2 57/4885ESR2 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.