Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA7 | P43166 | 1/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.48 |
| ▸ | ACHE | P22303 | 5/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622695 | 1.00 | CA1 (0.57) | CA1CA12CA7CA14SYK | |
| SCHEMBL2724479 | 0.82 | SYK (0.72) | SYKPPARACTSLATMMAPT | |
| SCHEMBL2724477 | 0.82 | SYK (0.72) | SYKPPARACTSLATMMAPT | |
| SCHEMBL18493490 | 0.82 | SYK (0.72) | SYKPPARACTSLATMMAPT | |
| SCHEMBL8283799 | 0.81 | CA1 (0.56) | CA1CA12CA7CA14SYK | |
| SCHEMBL8225131 | 0.78 | SYK (0.55) | SYKPPARACTSLATMMAPT | |
| SCHEMBL13622709 | 0.78 | SYK (0.44) | CA1CA12CA7CA14SYK | |
| SCHEMBL8284170 | 0.78 | SYK (0.44) | CA1CA12CA7CA14SYK | |
| SCHEMBL29206826 | 0.77 | CA1 (0.58) | CA1CA12CA7CA14SYK | |
| SCHEMBL8066895 | 0.77 | CA1 (0.68) | CA1CA12CA7CA14SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730142-B1 | NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS | SCHERING CORP (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2005085242-A1 | NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS | SCHERING CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |