Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCK1 | P16333 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.38 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284620 | 0.84 | SOS1 (0.41) | TLR8SOS1HTTCYP1A2CYP2D6 | |
| SCHEMBL8284629 | 0.83 | TLR8 (0.40) | TLR8SOS1HTTCYP1A2CYP2D6 | |
| SCHEMBL23295600 | 0.78 | TLR8 (0.58) | TLR8KCNH2SOS1HTTTNF | |
| SCHEMBL12226896 | 0.78 | PDE2A (0.47) | CYP1A2KMT2AALDH1A1PDE10A | |
| SCHEMBL8283862 | 0.78 | TLR8 (0.37) | TLR8KCNH2SOS1ACSS2TNF | |
| SCHEMBL8284617 | 0.76 | RPS6KA5 (0.47) | TLR8SOS1HTTCYP1A2CYP2D6 | |
| SCHEMBL8284623 | 0.75 | HTT (0.40) | TLR8SOS1HTTCYP1A2CYP2D6 | |
| SCHEMBL2335115 | 0.74 | TLR8 (0.91) | TLR8HTTCYP1A2CYP2D6POLB | |
| SCHEMBL21310823 | 0.72 | TLR8 (0.58) | TLR8KCNH2HTTCYP1A2CYP2D6 | |
| SCHEMBL16512956 | 0.72 | TLR8 (1.00) | TLR8POLBTLR7CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058869-A1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-06-30 | — | — | WO | disclosed |