Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 12/20 | 0.91 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16512956 | 0.95 | TLR8 (1.00) | TLR8POLBCXCR4TLR7TP53 | |
| SCHEMBL14447549 | 0.84 | TLR8 (0.71) | TLR8POLBCXCR4TLR7CYP1A2 | |
| SCHEMBL16512950 | 0.84 | TLR8 (1.00) | TLR8POLBCXCR4TP53 | |
| SCHEMBL2343059 | 0.80 | TLR8 (1.00) | TLR8POLBCXCR4CYP1A2CYP2D6 | |
| SCHEMBL2362286 | 0.76 | TLR8 (0.60) | TLR8POLB | |
| SCHEMBL939056 | 0.76 | TLR8 (0.56) | TLR8POLBTLR7TP53CDK9 | |
| SCHEMBL8108534 | 0.76 | TLR8 (0.59) | TLR8POLBTLR7TP53HTT | |
| SCHEMBL1704421 | 0.75 | TLR8 (0.58) | TLR8TLR7HTT | |
| SCHEMBL979518 | 0.75 | TLR8 (0.58) | TLR8TLR7HTT | |
| SCHEMBL1170110 | 0.75 | TLR8 (1.00) | TLR8POLBCXCR4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011099832-A2 | NOVEL BENZIMIDAZOLE COMPOUND, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | CRYSTALGENOMICS, INC. (KR) | 2011-08-18 | — | — | WO | disclosed |