Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.34 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284643 | 0.84 | HTT (0.39) | HTTPOLBALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL8284638 | 0.74 | CDK1 (0.37) | HTTPOLBALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL8284623 | 0.74 | HTT (0.40) | HTTPOLBALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL8285688 | 0.72 | SOS1 (0.46) | HTTPOLBALDH1A1TNFNOD2 | |
| SCHEMBL8283840 | 0.72 | TNF (0.40) | HTTPOLBALDH1A1TNFNOD2 | |
| SCHEMBL8285693 | 0.72 | TNF (0.40) | HTTPOLBALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL6270643 | 0.71 | BACE1 (0.39) | HTTPOLBALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL8284699 | 0.70 | ALDH1A1 (0.40) | HTTPOLBALDH1A1TLR8TNF | |
| SCHEMBL8284702 | 0.69 | ALDH1A1 (0.46) | HTTPOLBALDH1A1PTGDR2 | |
| SCHEMBL8286225 | 0.66 | CSF1R (0.53) | HTTPOLBALDH1A1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058869-A1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-06-30 | — | — | WO | disclosed |