Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287850 | 0.94 | PDE11A (0.56) | PDE11AADORA2APTGS2PTK2LMNA | |
| SCHEMBL8286369 | 0.87 | PDE11A (0.59) | PDE11ATSHRKDM4ELMNAGAA | |
| SCHEMBL8287114 | 0.87 | PDE11A (0.59) | PDE11ACYP1A2CYP2C19CYP2C9HSD17B10 | |
| SCHEMBL8287908 | 0.86 | PDE11A (0.45) | PDE11AMAT2AKDM4EADORA3ADORA2A | |
| SCHEMBL8287838 | 0.86 | PDE11A (0.57) | PDE11ACYP1A2TSHRCYP2C19CYP2C9 | |
| SCHEMBL8287507 | 0.85 | PDE11A (0.59) | PDE11ACYP1A2TSHRHSD17B10MAT2A | |
| SCHEMBL8287857 | 0.85 | PDE11A (0.56) | PDE11ACYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL8285152 | 0.85 | PDE11A (0.56) | PDE11ALMNAMAPTMEN1KMT2A | |
| SCHEMBL8285156 | 0.84 | PDE11A (0.56) | PDE11ACYP1A2MAT2AKDM4EPTK2 | |
| SCHEMBL8285267 | 0.84 | PDE11A (0.62) | PDE11ACYP1A2PTK2LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |