Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287114 | 0.89 | PDE11A (0.59) | PDE11ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL8287857 | 0.88 | PDE11A (0.56) | PDE11ATSHRLMNAALDH1A1KDM4E | |
| SCHEMBL8285142 | 0.87 | PDE11A (0.60) | PDE11ATSHRLMNAALDH1A1KDM4E | |
| SCHEMBL8287838 | 0.87 | PDE11A (0.57) | PDE11ATSHRLMNAALDH1A1KDM4E | |
| SCHEMBL8287115 | 0.86 | PDE11A (0.44) | PDE11ATSHRRECQLMCL1LMNA | |
| SCHEMBL8285152 | 0.86 | PDE11A (0.56) | PDE11ALMNAALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL8285156 | 0.85 | PDE11A (0.56) | PDE11ALMNAALDH1A1KDM4EHCRTR1 | |
| SCHEMBL8287845 | 0.84 | PDE11A (0.55) | PDE11ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL8287850 | 0.84 | PDE11A (0.56) | PDE11ALMNAKCNH3CNR2MAPT | |
| SCHEMBL8287840 | 0.84 | PDE11A (0.54) | PDE11ALMNAALDH1A1KDM4EHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |