Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | TP53 | P04637 | 6/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286344 | 0.95 | PDE11A (0.64) | PDE11AKMT2AMAPTTP53CDK4 | |
| SCHEMBL8286346 | 0.93 | PDE11A (0.61) | PDE11AKMT2AMAPTTP53ALDH1A1 | |
| SCHEMBL8286342 | 0.92 | PDE11A (0.60) | PDE11AKMT2AMAPTTP53ALDH1A1 | |
| SCHEMBL5871831 | 0.90 | PDE11A (0.57) | PDE11AKMT2AMAPTTP53CDK4 | |
| SCHEMBL5872109 | 0.90 | PDE11A (0.75) | PDE11AMAPTALDH1A1PIK3CDPIK3CA | |
| SCHEMBL5871598 | 0.90 | PDE11A (0.58) | PDE11AKMT2ACDK4CCND1CCND2 | |
| SCHEMBL8287870 | 0.89 | PDE11A (0.56) | PDE11AMAPTTP53CDK4CCND1 | |
| SCHEMBL8285164 | 0.88 | PDE11A (0.55) | PDE11AKMT2AMAPTTP53CDK4 | |
| SCHEMBL8286050 | 0.88 | PDE11A (0.54) | PDE11AKMT2AMAPTHSD17B10LMNA | |
| SCHEMBL8286054 | 0.88 | PDE11A (0.54) | PDE11AMAPTTP53ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |