Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | GALR2 | O43603 | 2/20 | 0.39 |
| ▸ | GALR1 | P47211 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286342 | 0.99 | PDE11A (0.60) | PDE11AGAAKDM4EL3MBTL1ACHE | |
| SCHEMBL8286344 | 0.94 | PDE11A (0.64) | PDE11AKDM4EL3MBTL1ALDH1A1POLB | |
| SCHEMBL8285166 | 0.93 | PDE11A (0.60) | PDE11AKDM4EALDH1A1POLBPIK3CD | |
| SCHEMBL5872109 | 0.91 | PDE11A (0.75) | PDE11AGAAKDM4EALDH1A1HPGD | |
| SCHEMBL5871598 | 0.91 | PDE11A (0.58) | PDE11AKDM4EALDH1A1POLBHPGD | |
| SCHEMBL5871831 | 0.89 | PDE11A (0.57) | PDE11AALDH1A1POLBPIK3CDPIK3CA | |
| SCHEMBL8287870 | 0.88 | PDE11A (0.56) | PDE11AKDM4EALDH1A1PIK3CDPIK3CA | |
| SCHEMBL8285164 | 0.87 | PDE11A (0.55) | PDE11AKDM4EALDH1A1PIK3CDPIK3CA | |
| SCHEMBL8286050 | 0.86 | PDE11A (0.54) | PDE11AGAAPOLBMAPTKMT2A | |
| SCHEMBL8286054 | 0.86 | PDE11A (0.54) | PDE11AKDM4EALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |