Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.34 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872005 | 0.88 | MAT2A (0.43) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL8287374 | 0.85 | PDE11A (0.40) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL8285182 | 0.83 | PDE11A (0.39) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL5872009 | 0.82 | PDE11A (0.44) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL5872062 | 0.80 | PDE11A (0.44) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL8287383 | 0.79 | PDE11A (0.41) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL5872128 | 0.78 | PDE11A (0.43) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL8287382 | 0.78 | PDE11A (0.43) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL5871661 | 0.78 | PDE11A (0.42) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 | |
| SCHEMBL8287521 | 0.77 | PDE11A (0.40) | PDE11AGSK3BALDH1A1ALDH1A3ALDH1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |