Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | ATP4A | P20648 | 2/20 | 0.39 |
| ▸ | ATP4B | P51164 | 2/20 | 0.39 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871760 | 0.87 | HDAC1 (0.39) | TP53PDE11AHDAC1HDAC8HDAC6 | |
| SCHEMBL5871748 | 0.87 | HDAC1 (0.39) | TP53PDE11AHDAC1HDAC8HDAC6 | |
| SCHEMBL8285212 | 0.86 | HDAC1 (0.40) | LMNATP53PDE11AALDH1A1HDAC1 | |
| SCHEMBL8285204 | 0.85 | HDAC1 (0.38) | TP53PDE11AHDAC1HDAC8HDAC6 | |
| SCHEMBL8287362 | 0.85 | HDAC1 (0.41) | TP53PDE11AHDAC1HDAC8HDAC6 | |
| SCHEMBL5872140 | 0.85 | HDAC1 (0.37) | LMNATP53PDE11AALDH1A1HDAC1 | |
| SCHEMBL5872137 | 0.85 | HDAC1 (0.37) | LMNATP53PDE11AALDH1A1HDAC1 | |
| SCHEMBL5871894 | 0.84 | PDE11A (0.43) | LMNAPDE11AALDH1A1GAAMEN1 | |
| SCHEMBL8287126 | 0.84 | HDAC1 (0.37) | TP53PDE11AHDAC1HDAC8HDAC6 | |
| SCHEMBL8287451 | 0.83 | PDE11A (0.42) | LMNAPDE11AALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |