Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871748 | 0.92 | HDAC1 (0.39) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL5871760 | 0.92 | HDAC1 (0.39) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL8285212 | 0.91 | HDAC1 (0.40) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL8287362 | 0.89 | HDAC1 (0.41) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL5872140 | 0.89 | HDAC1 (0.37) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL5872137 | 0.89 | HDAC1 (0.37) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL8287126 | 0.88 | HDAC1 (0.37) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL8285201 | 0.85 | LMNA (0.40) | HDAC1HDAC8HDAC6HDAC10HDAC2 | |
| SCHEMBL8285237 | 0.81 | ALDH1A1 (0.41) | PDE11APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8287456 | 0.81 | PDE11A (0.42) | PDE11AGSK3BGAAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |