Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285192 | 0.91 | PDE11A (0.42) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8286065 | 0.88 | PDE11A (0.46) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8285170 | 0.84 | PDE11A (0.46) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8285162 | 0.82 | PDE11A (0.43) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8285168 | 0.80 | PDE11A (0.42) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8285222 | 0.80 | PDE11A (0.41) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8285184 | 0.80 | PDE11A (0.47) | PDE11AGSK3BKDM4ERIPK1PDE4A | |
| SCHEMBL8286060 | 0.79 | PDE11A (0.46) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8287158 | 0.76 | PDE11A (0.41) | PDE11AGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8287127 | 0.75 | PDE11A (0.59) | PDE11AKDM4EALDH1A1ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |