Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RHOA | P61586 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287161 | 0.90 | PDE11A (0.38) | PDE11AMAPTTP53LMNAALDH1A1 | |
| SCHEMBL5872128 | 0.86 | PDE11A (0.43) | PDE11AGSK3BMAPTTP53LMNA | |
| SCHEMBL5871748 | 0.82 | HDAC1 (0.39) | PDE11ACSNK2A1AURKAGSK3AGSK3B | |
| SCHEMBL5871760 | 0.82 | HDAC1 (0.39) | PDE11ACSNK2A1AURKAGSK3AGSK3B | |
| SCHEMBL8287382 | 0.82 | PDE11A (0.43) | PDE11AAURKAGSK3BMAPTTP53 | |
| SCHEMBL8287383 | 0.80 | PDE11A (0.41) | PDE11AGSK3BTP53ALDH1A1ALDH1A2 | |
| SCHEMBL5871780 | 0.80 | PDE11A (0.41) | PDE11ACSNK2A1AURKAMAPTALDH1A1 | |
| SCHEMBL5872062 | 0.79 | PDE11A (0.44) | PDE11AGSK3BMAPTLMNAALDH1A1 | |
| SCHEMBL5872009 | 0.79 | PDE11A (0.44) | PDE11AGSK3BLMNAALDH1A1ALDH1A2 | |
| SCHEMBL8285211 | 0.79 | RAB9A (0.42) | PDE11AAURKAGSK3AGSK3BACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |