Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.35 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.35 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286473 | 0.90 | GSK3B (0.36) | CCNCCDK8KMT2ASMN1; SMN2GAA | |
| SCHEMBL8287251 | 0.82 | GAA (0.36) | KDM4EKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL5872140 | 0.80 | HDAC1 (0.37) | CCNCCDK8IP6K1IP6K3IP6K2 | |
| SCHEMBL5872137 | 0.80 | HDAC1 (0.37) | CCNCCDK8IP6K1IP6K3IP6K2 | |
| SCHEMBL8286163 | 0.79 | BRAF (0.40) | KDM4EKMT2AALDH1A1MAPTGAA | |
| SCHEMBL8285273 | 0.78 | KDM4E (0.36) | NFE2L2IP6K1IP6K3IP6K2KDM4E | |
| SCHEMBL8287117 | 0.78 | KDM4E (0.46) | NFE2L2IP6K1IP6K3IP6K2KDM4E | |
| SCHEMBL8287991 | 0.78 | GAA (0.39) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL8287214 | 0.78 | GAA (0.44) | KDM4EKMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL8286174 | 0.77 | BRAF (0.39) | KDM4EKMT2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |