Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.33 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287440 | 0.90 | GSK3B (0.36) | KDM4ESMN1; SMN2GSK3BEGFRBTK | |
| SCHEMBL8287196 | 0.82 | GSK3B (0.37) | KDM4EKMT2ASMN1; SMN2GSK3BEGFR | |
| SCHEMBL8287117 | 0.80 | KDM4E (0.46) | KDM4EKMT2ASMN1; SMN2MLYCDGSK3B | |
| SCHEMBL8287576 | 0.79 | GSK3B (0.39) | KMT2AGSK3BEGFRMAPTALDH1A1 | |
| SCHEMBL8287201 | 0.78 | GSK3B (0.34) | KDM4EKMT2AGSK3BEGFRBTK | |
| SCHEMBL8285289 | 0.78 | CCNC (0.37) | KDM4EKMT2ASMN1; SMN2MLYCDGSK3B | |
| SCHEMBL8286468 | 0.78 | GSK3B (0.38) | KDM4EKMT2ASMN1; SMN2GSK3BEGFR | |
| SCHEMBL8287593 | 0.78 | GSK3B (0.37) | KMT2ASMN1; SMN2GSK3BEGFRBTK | |
| SCHEMBL5872050 | 0.78 | GAA (0.44) | KMT2ASMN1; SMN2GSK3BMAPTALDH1A1 | |
| SCHEMBL8287912 | 0.77 | TSHR (0.38) | KDM4EKMT2ASMN1; SMN2GSK3BSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |