Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872108 | 0.86 | GAA (0.44) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL8287944 | 0.85 | GAA (0.43) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL8286573 | 0.84 | GAA (0.42) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL5871824 | 0.84 | GAA (0.44) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL8287934 | 0.84 | MAT2A (0.43) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL5872043 | 0.83 | GAA (0.41) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL5871645 | 0.82 | GAA (0.42) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL5871993 | 0.82 | PDE11A (0.52) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL8286459 | 0.82 | PDE11A (0.41) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL8286460 | 0.82 | PDE11A (0.43) | ALDH1A1PDE11AGAAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |