Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288007 | 0.88 | SLC18A3 (0.49) | SLC18A3SIGMAR1 | |
| SCHEMBL8287288 | 0.88 | SLC18A3 (0.55) | SLC18A3SIGMAR1 | |
| SCHEMBL8285368 | 0.88 | SLC18A3 (0.51) | SLC18A3SIGMAR1 | |
| SCHEMBL5557070 | 0.74 | SLC6A9 (0.48) | — | |
| SCHEMBL14573345 | 0.74 | SLC6A9 (0.48) | — | |
| SCHEMBL5557067 | 0.74 | SLC6A9 (0.48) | — | |
| SCHEMBL8287620 | 0.74 | CA12 (0.42) | SLC18A3 | |
| SCHEMBL27539703 | 0.73 | CA12 (0.43) | SLC18A3SIGMAR1 | |
| SCHEMBL27455915 | 0.73 | CA12 (0.43) | SLC18A3SIGMAR1 | |
| SCHEMBL11592218 | 0.73 | OPRL1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678177-B1 | TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | HOFFMANN LA ROCHE (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2005040166-A1 | TRIAZA-SPIROPIPERIDINE DERIVATIVES FOR USE AS GLYT-1 INHIBITORS IN THE TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |