Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286352 | 0.89 | PDE11A (0.60) | PDE11AHCRTR1HCRTR2GAA | |
| SCHEMBL8287367 | 0.88 | PDE11A (0.49) | PDE11AP2RX3HCRTR1HCRTR2NR3C1 | |
| SCHEMBL8287361 | 0.86 | PDE11A (0.48) | PDE11AP2RX3HCRTR1HCRTR2NR3C1 | |
| SCHEMBL8287868 | 0.85 | PDE11A (0.47) | PDE11AP2RX3HCRTR1HCRTR2MDM2 | |
| SCHEMBL8286091 | 0.84 | PDE11A (0.46) | PDE11AHCRTR1HCRTR2METAXL | |
| SCHEMBL8287120 | 0.78 | PDE11A (0.49) | PDE11AMDM2KDM4EGAAHPGD | |
| SCHEMBL8286094 | 0.78 | PDE11A (0.45) | PDE11AMETAXLKDM4EGAA | |
| SCHEMBL8287364 | 0.77 | PDE11A (0.47) | PDE11AMETAXLMDM2GAA | |
| SCHEMBL8287101 | 0.76 | PDE11A (0.60) | PDE11AHCRTR1HCRTR2 | |
| SCHEMBL8287391 | 0.76 | PDE11A (0.81) | PDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |