Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 4/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287096 | 0.87 | PDE11A (0.60) | PDE11AMEN1KMT2AAURKAGAA | |
| SCHEMBL8287365 | 0.84 | GRM5 (0.38) | PDE11AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8287361 | 0.79 | PDE11A (0.48) | PDE11AALDH1A1MET | |
| SCHEMBL8287120 | 0.79 | PDE11A (0.49) | PDE11AMAPK10GAAMDM2 | |
| SCHEMBL8287367 | 0.79 | PDE11A (0.49) | PDE11AMDM2 | |
| SCHEMBL8286090 | 0.77 | PDE11A (0.48) | PDE11AGAAMDM2METAXL | |
| SCHEMBL8286091 | 0.77 | PDE11A (0.46) | PDE11AMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8287391 | 0.76 | PDE11A (0.81) | PDE11ACYP3A4MAPK10 | |
| SCHEMBL8286094 | 0.74 | PDE11A (0.45) | PDE11AMEN1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8286093 | 0.74 | PDE11A (0.59) | PDE11AMEN1KMT2AAURKAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |