Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286442 | 0.89 | ALDH1A1 (0.42) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL8286447 | 0.87 | PDE11A (0.41) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5871894 | 0.84 | PDE11A (0.43) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL8287451 | 0.83 | PDE11A (0.42) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL8287866 | 0.82 | CYP3A4 (0.39) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL8361773 | 0.82 | PDE11A (0.44) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL8287456 | 0.82 | PDE11A (0.42) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5872009 | 0.82 | PDE11A (0.44) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL5871540 | 0.82 | PDE11A (0.42) | PDE11ACYP1A2CYP2C9CYP3A4ALDH1A1 | |
| SCHEMBL8285224 | 0.81 | PDE11A (0.41) | PDE11ACYP2C9ALDH1A1CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |