Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND2 | P30279 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287617 | 0.88 | GSK3B (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286150 | 0.88 | GSK3B (0.39) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287945 | 0.88 | S1PR1 (0.39) | GSK3BS1PR1CDK4CCND1CCND2 | |
| SCHEMBL8287455 | 0.87 | MAT2A (0.36) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286148 | 0.87 | GSK3B (0.36) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287917 | 0.86 | GSK3B (0.36) | GSK3BS1PR1CDK4CCND1CCND2 | |
| SCHEMBL8287498 | 0.85 | GSK3B (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286453 | 0.85 | GSK3B (0.35) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8287939 | 0.85 | MIF (0.41) | GAAHPGDALDH1A1MAPT | |
| SCHEMBL8286574 | 0.84 | MAT2A (0.39) | GSK3BCDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |