Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286390 | 0.92 | PDE11A (0.40) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL8287518 | 0.88 | PDE11A (0.44) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL5872175 | 0.87 | PDE11A (0.47) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL8286396 | 0.87 | PDE11A (0.44) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL5871541 | 0.86 | PDE11A (0.46) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL8285174 | 0.86 | PDE11A (0.43) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL8287397 | 0.85 | PDE11A (0.46) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL8287393 | 0.85 | PDE11A (0.46) | KDM4EHTTPDE11AHPGDALDH1A1 | |
| SCHEMBL8286384 | 0.85 | PDE11A (0.42) | CSF1RKDM4EHTTPDE11AHPGD | |
| SCHEMBL8285169 | 0.85 | PDE11A (0.45) | CSF1RKDM4EHTTPDE11AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |