Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285235 | 0.88 | PDE11A (0.41) | PDE11AALDH1A1LMNAGSK3BCYP1A2 | |
| SCHEMBL8286420 | 0.86 | PDE11A (0.40) | PDE11AALDH1A1LMNAGSK3BCYP1A2 | |
| SCHEMBL8287150 | 0.86 | PDE11A (0.40) | PDE11AALDH1A1LMNAGSK3BCYP1A2 | |
| SCHEMBL8287503 | 0.86 | PDE11A (0.40) | PDE11AALDH1A1LMNAGSK3BCYP1A2 | |
| SCHEMBL8285219 | 0.85 | PDE11A (0.39) | PDE11AALDH1A1LMNAGSK3BCYP1A2 | |
| SCHEMBL8286131 | 0.85 | MAPT (0.42) | PDE11AALDH1A1LMNAGSK3BCASP1 | |
| SCHEMBL8287888 | 0.85 | KDM4E (0.44) | PDE11AALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL8287564 | 0.84 | ALDH1A1 (0.38) | PDE11AALDH1A1LMNAUSP2TSHR | |
| SCHEMBL8285233 | 0.84 | PDE11A (0.39) | PDE11AALDH1A1LMNAGSK3BCYP1A2 | |
| SCHEMBL8287892 | 0.84 | PDE11A (0.39) | PDE11AALDH1A1LMNAGSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |