Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAP | Q12884 | 13/20 | 0.73 |
| ▸ | PREP | P48147 | 7/20 | 0.73 |
| ▸ | DPP4 | P27487 | 17/20 | 0.67 |
| ▸ | DPP7 | Q9UHL4 | 15/20 | 0.67 |
| ▸ | DPP8 | Q6V1X1 | 13/20 | 0.67 |
| ▸ | DPP9 | Q86TI2 | 12/20 | 0.67 |
| ▸ | PITRM1 | Q5JRX3 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13347225 | 1.00 | FAP (0.73) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL18084196 | 0.86 | FAP (0.71) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL8249904 | 0.84 | FAP (1.00) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL8243719 | 0.84 | FAP (1.00) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL21746363 | 0.84 | DPP4 (0.74) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL21746362 | 0.84 | DPP4 (0.74) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL8286526 | 0.83 | DPP4 (0.73) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL19697089 | 0.80 | DPP4 (0.65) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL8286523 | 0.80 | DPP4 (1.00) | FAPPREPDPP4DPP7DPP8 | |
| SCHEMBL13347226 | 0.80 | DPP4 (0.67) | FAPPREPDPP4DPP7DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9192646-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | BACH BIOSCIENCES, LLC | 2015-06-11 | — | — | US | disclosed |
| US-8933056-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2014-05-08 | — | — | US | disclosed |
| US-8563533-B2 | Soft protease inhibitors and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-10-22 | — | — | US | disclosed |
| US-20130150292-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-06-13 | — | — | US | disclosed |
| US-20100120661-A1 | HETEROCYCLIC BORONIC ACID COMPOUNDS | PHENOMIX CORPORATION (US) | 2010-05-13 | — | — | US | disclosed |
| US-7674913-B2 | Heterocyclic boronic acid compounds | PHENOMIX CORPORATION (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1997533-A1 | Heterocyclic boronic acid compounds, dipeptidyl peptidase IV inhibitors | Phenomix Corporation (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2005047297-A1 | HETEROCYCLIC BORONIC ACID COMPOUNDS | PHENOMIX CORPORATION (US) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130150292-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | FAP 51/4885PREP 1/4885DPP4 2/4885 |
| US-20150157684-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | FAP 51/4885PREP 1/4885DPP4 2/4885 |
| US-20140128344-A1 | Soft Protease Inhibitors and Pro-Soft Forms Thereof | PREP, DPP4, PEPD | FAP 51/4885PREP 1/4885DPP4 2/4885 |
| US-20100120661-A1 | HETEROCYCLIC BORONIC ACID COMPOUNDS | DPP4, DPP7, DPP3 | FAP 238/4885PREP 465/4885DPP4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.