Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287137 | 0.88 | PDE11A (0.44) | PDE11AGAATSHRPOLBHTT | |
| SCHEMBL5871799 | 0.87 | PDE11A (0.50) | PDE11AGAATSHRPOLBHTT | |
| SCHEMBL8287908 | 0.86 | PDE11A (0.45) | PDE11ARECQLSLC2A1HTTSMN1; SMN2 | |
| SCHEMBL8362727 | 0.86 | PDE11A (0.46) | PDE11AGAAIKBKBKMT2AHPGD | |
| SCHEMBL8286369 | 0.86 | PDE11A (0.59) | PDE11ARECQLMCL1GAATSHR | |
| SCHEMBL5871404 | 0.84 | PDE11A (0.44) | PDE11AGAATSHRPOLBSLC2A1 | |
| SCHEMBL5871689 | 0.84 | PDE11A (0.46) | PDE11AGAATSHRPOLBHTT | |
| SCHEMBL8286057 | 0.83 | KDM4E (0.44) | PDE11ARECQLGAATSHRHTT | |
| SCHEMBL8285161 | 0.83 | PDE11A (0.47) | PDE11AGAAPOLBHTTSMN1; SMN2 | |
| SCHEMBL8285163 | 0.82 | POLB (0.50) | PDE11AGAATSHRPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |