Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871645 | 0.86 | GAA (0.42) | ALDH1A1TSHRPDE11AMAPTHPGD | |
| SCHEMBL5872094 | 0.85 | PDE11A (0.40) | ALDH1A1TSHRPDE11AKMT2AMEN1 | |
| SCHEMBL8287996 | 0.84 | MAPT (0.43) | ALDH1A1PDE11AKMT2AMEN1MAPT | |
| SCHEMBL8286146 | 0.84 | PDE11A (0.39) | ALDH1A1TSHRPDE11AMAPTHPGD | |
| SCHEMBL8287994 | 0.84 | PDE11A (0.38) | ALDH1A1TSHRPDE11AKMT2AMEN1 | |
| SCHEMBL8287217 | 0.83 | RIPK1 (0.43) | ALDH1A1TSHRPDE11AKMT2AMEN1 | |
| SCHEMBL8286412 | 0.83 | PDE11A (0.46) | ALDH1A1TSHRPDE11AKMT2AMEN1 | |
| SCHEMBL8287535 | 0.83 | PDE4B (0.41) | ALDH1A1PDE11AKMT2AMEN1MAPT | |
| SCHEMBL8287219 | 0.82 | CNR2 (0.47) | ALDH1A1TSHRKMT2AMEN1MAPT | |
| SCHEMBL8287408 | 0.82 | PDE11A (0.44) | ALDH1A1TSHRPDE11AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |