Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 14/20 | 0.81 |
| ▸ | DRD4 | P21917 | 13/20 | 0.81 |
| ▸ | DRD2 | P14416 | 13/20 | 0.81 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.81 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | FAAH | O00519 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | DRD1 | P21728 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.59 |
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286909 | 0.90 | DRD3 (1.00) | DRD3DRD4DRD2SIGMAR1HTR2A | |
| SCHEMBL8286906 | 0.83 | DRD2 (1.00) | DRD3DRD4DRD2SIGMAR1 | |
| SCHEMBL13637989 | 0.83 | DRD2 (0.84) | DRD3DRD4DRD2SIGMAR1HTR2A | |
| SCHEMBL7433461 | 0.78 | DRD2 (0.72) | DRD3DRD4DRD2SIGMAR1HTR2A | |
| SCHEMBL6978822 | 0.78 | DRD3 (1.00) | DRD3DRD4DRD2SIGMAR1 | |
| SCHEMBL7114888 | 0.78 | DRD2 (0.73) | DRD3DRD4DRD2SIGMAR1 | |
| SCHEMBL14495145 | 0.77 | DRD2 (0.75) | DRD3DRD4DRD2SIGMAR1HTR2A | |
| SCHEMBL14495136 | 0.77 | DRD2 (0.73) | DRD3DRD4DRD2SIGMAR1HTR2A | |
| SCHEMBL14494851 | 0.77 | DRD2 (0.62) | DRD3DRD4DRD2SIGMAR1HTR2A | |
| SCHEMBL3408334 | 0.76 | DRD3 (0.77) | DRD3DRD4DRD2HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005048810-A2 | SIGMA-2 RECEPTOR RADIOTRACERS FOR IMAGING THE PROLIFERATIVE STATUS OF SOLID TUMORS | WASHINGTON UNIVERSITY IN ST. LOUIS (US) | 2005-06-02 | — | — | WO | disclosed |