Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | MAT2A | P31153 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362920 | 0.88 | PDE11A (0.38) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8285285 | 0.87 | PDE11A (0.36) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8287207 | 0.85 | CYP1A2 (0.41) | PDE11AMAPK1NPSR1ALDH1A1LMNA | |
| SCHEMBL8287979 | 0.85 | PDE11A (0.37) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8287193 | 0.84 | MAPT (0.40) | PDE11AGSK3BALDH1A1CSF1RTSHR | |
| SCHEMBL8286460 | 0.83 | PDE11A (0.43) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8287190 | 0.82 | PDE11A (0.40) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8287534 | 0.81 | PDE11A (0.34) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8286421 | 0.81 | PDE11A (0.39) | PDE11AGAAHPGDMAPK1NPSR1 | |
| SCHEMBL8286190 | 0.81 | MAPT (0.40) | PDE11AGAAHPGDMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |