SCHEMBL8286190

SCHEMBL8286190

Cc1cc2c(c(CNc3ccccc3)n1)c(=O)cc(Nc1ccccc1)n2-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.40
PDE11A Q9HCR9 1/20 0.39
GAA P10253 7/20 0.39
HPGD P15428 2/20 0.39
MAPK1 P28482 2/20 0.39
CCNE1 P24864 3/20 0.37
CDK2 P24941 3/20 0.37
CDK1 P06493 1/20 0.37
CCNB1 P14635 1/20 0.37
LMNA P02545 3/20 0.37
HTT P42858 3/20 0.37
ALDH1A1 P00352 3/20 0.37
NPSR1 Q6W5P4 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
KDM4E B2RXH2 2/20 0.36
GPR55 Q9Y2T6 1/20 0.36
ATM Q13315 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
TSHR P16473 1/20 0.36
GSK3B P49841 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8286460 0.89 PDE11A (0.43) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8287190 0.88 PDE11A (0.40) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8286421 0.87 PDE11A (0.39) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8287610 0.86 PDE11A (0.39) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8286189 0.86 PDE11A (0.39) PDE11AGAAHPGDMAPK1LMNA
SCHEMBL8286191 0.86 KCNH3 (0.37) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8286575 0.86 PDE11A (0.38) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8287209 0.84 PLA2G4A (0.38) MAPTPDE11AGAAHPGDMAPK1
SCHEMBL8362920 0.84 PDE11A (0.38) PDE11AGAAHPGDMAPK1LMNA
SCHEMBL5872108 0.84 GAA (0.44) MAPTPDE11AGAAHPGDMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005091857-A2 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2005-10-06 WO disclosed
WO-2003027112-A1 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS BAYER PHARMACEUTICALS CORPORATION (US) 2003-04-03 WO disclosed