Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365895 | 0.88 | KCNH2 (0.55) | KCNH2FFAR1GRM5MAOBSYK | |
| SCHEMBL19772940 | 0.80 | SYK (0.47) | FFAR1GRM5SYKMAPTSMN1; SMN2 | |
| SCHEMBL13232411 | 0.79 | KCNH2 (0.56) | KCNH2GRM5MAPTSMN1; SMN2PDE10A | |
| SCHEMBL16710556 | 0.78 | KCNH2 (0.47) | KCNH2FFAR1GRM5MAOBGPBAR1 | |
| SCHEMBL1314202 | 0.78 | KCNH2 (0.55) | KCNH2FFAR1GRM5SMN1; SMN2PDE10A | |
| SCHEMBL8288269 | 0.78 | MAOB (0.56) | KCNH2MAOBMAPTSMN1; SMN2 | |
| SCHEMBL8285904 | 0.78 | CYP3A4 (0.53) | KCNH2FFAR1GRM5MAOBAPP | |
| SCHEMBL23472697 | 0.77 | KCNH2 (0.49) | KCNH2GRM5PDE10A | |
| SCHEMBL1711764 | 0.77 | KCNH2 (0.53) | KCNH2FFAR1GRM5SYKSMN1; SMN2 | |
| SCHEMBL10860252 | 0.77 | KCNH2 (0.53) | KCNH2GRM5MAOBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044265-A1 | ALKYNES III | ASTRAZENECA AB (SE) | 2005-05-19 | — | — | WO | disclosed |