Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511298 | 0.90 | TACR1 (0.40) | PTGS2LMNATACR1ALDH1A1GAA | |
| SCHEMBL17568824 | 0.86 | LMNA (0.36) | PTGS2LMNATACR1SMN1; SMN2ATM | |
| SCHEMBL7532125 | 0.86 | LMNA (0.46) | LMNAL3MBTL1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7527783 | 0.85 | LMNA (0.38) | LMNATACR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL7532198 | 0.85 | LMNA (0.39) | PTGS2LMNATACR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7531882 | 0.85 | LMNA (0.37) | LMNATACR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL7528118 | 0.84 | LMNA (0.37) | LMNATACR1ALDH1A1GAAL3MBTL1 | |
| SCHEMBL7526605 | 0.83 | LMNA (0.51) | LMNAALDH1A1L3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL7526362 | 0.82 | LMNA (0.37) | LMNASMN1; SMN2PPARG | |
| SCHEMBL7532384 | 0.82 | SMN1; SMN2 (0.45) | LMNATACR1SMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058311-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2005-06-30 | — | — | WO | disclosed |