Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 9/20 | 0.63 |
| ▸ | GRIA4 | P48058 | 9/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289796 | 0.88 | GRIA2 (0.81) | GRIA2GRIA4PDE10A | |
| SCHEMBL8288396 | 0.88 | GRIA4 (0.59) | GRIA2GRIA4 | |
| SCHEMBL8288392 | 0.85 | GRIA4 (0.61) | GRIA2GRIA4 | |
| SCHEMBL4381939 | 0.82 | HTT (0.46) | GRIA2GRIA4 | |
| SCHEMBL8289345 | 0.80 | GRIA2 (0.80) | GRIA2GRIA4 | |
| SCHEMBL8288323 | 0.80 | GRIA2 (0.55) | GRIA2GRIA4PDE10A | |
| SCHEMBL8288318 | 0.79 | GRIA4 (0.77) | GRIA2GRIA4 | |
| SCHEMBL8288352 | 0.79 | GRIA4 (0.59) | GRIA2GRIA4 | |
| SCHEMBL8287321 | 0.79 | GRIA4 (0.59) | GRIA2GRIA4 | |
| SCHEMBL8287546 | 0.78 | GRIA4 (1.00) | GRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670757-B1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | LILLY CO ELI (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |