Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 12/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4381290 | 0.90 | GRIA2 (0.55) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL13611763 | 0.90 | GRIA4 (0.41) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL4375372 | 0.88 | GRIA4 (0.40) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL4369403 | 0.83 | GRIA4 (0.63) | GRIA4GRIA2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4486927 | 0.82 | KDM4E (0.41) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL4371152 | 0.81 | GRIA4 (0.56) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8289380 | 0.81 | GRIA4 (0.52) | GRIA4GRIA2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4378375 | 0.80 | GRIA4 (0.73) | GRIA4GRIA2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4381305 | 0.80 | GRIA4 (0.55) | GRIA4GRIA2ALDH1A1KDM4EHPGD | |
| SCHEMBL8288389 | 0.79 | ALDH1A1 (0.45) | GRIA4GRIA2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005040110-A1 | PYRROLE AND PYRAZOLE DERIVATIVES AS POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2005-05-06 | — | — | WO | disclosed |