Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.80 |
| ▸ | MEN1 | O00255 | 5/20 | 0.80 |
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.57 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472036 | 0.93 | KMT2A (0.69) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3911790 | 0.91 | KMT2A (0.81) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3914480 | 0.89 | MAPT (1.00) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8289674 | 0.83 | ALDH1A1 (0.80) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL6435364 | 0.81 | KMT2A (0.85) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3922647 | 0.80 | MAPT (0.59) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3914109 | 0.80 | MEN1 (1.00) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL8289814 | 0.79 | MAPT (0.81) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3914440 | 0.78 | MEN1 (1.00) | KMT2AMEN1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL3913942 | 0.77 | KMT2A (0.85) | KMT2AMEN1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |