Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | CRHBP | P24387 | 1/20 | 0.71 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | FLT3 | P36888 | 7/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | CLK1 | P49759 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288765 | 0.92 | MAPT (0.98) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23711014 | 0.88 | MAPT (0.81) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL21651804 | 0.87 | MAPT (0.98) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8290348 | 0.82 | MAPT (0.75) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14666759 | 0.81 | MAPT (1.00) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8290663 | 0.81 | FLT3 (1.00) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8289853 | 0.80 | FLT3 (0.97) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8289526 | 0.80 | RAB9A (0.95) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5463079 | 0.80 | FLT3 (1.00) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3128198 | 0.80 | FLT3 (1.00) | MAPTALDH1A1SMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |