Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 7/20 | 0.65 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.65 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.65 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.65 |
| ▸ | GCGR | P47871 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288821 | 0.91 | GCGR (0.72) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8290417 | 0.89 | GCGR (0.64) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5453560 | 0.85 | POLB (0.67) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL5447380 | 0.85 | MAPT (0.72) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8290635 | 0.82 | FLT3 (0.67) | MAPTALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL3916246 | 0.81 | MAPT (0.78) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8289514 | 0.80 | AIP (0.69) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8289715 | 0.80 | MAPT (0.67) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8289505 | 0.79 | AIP (0.68) | POLBMAPTDUSP3PTPN5PTPN11 | |
| SCHEMBL8290420 | 0.79 | POLB (0.65) | POLBMAPTDUSP3PTPN5PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |