Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.74 |
| ▸ | POLB | P06746 | 4/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.69 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290673 | 0.88 | FLT3 (0.78) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468612 | 0.84 | MAPT (0.78) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL8289522 | 0.83 | TP53 (0.75) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468545 | 0.80 | POLB (0.83) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468593 | 0.79 | POLB (0.85) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468552 | 0.78 | POLB (0.83) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL8289622 | 0.78 | POLB (0.76) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468519 | 0.78 | POLB (0.72) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468588 | 0.78 | POLB (0.82) | MAPTPOLBTP53THRBALDH1A1 | |
| SCHEMBL34468516 | 0.77 | POLB (0.71) | MAPTPOLBTP53THRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |