Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.78 |
| ▸ | ATM | Q13315 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | FLT3 | P36888 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.67 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 4/20 | 0.64 |
| ▸ | KIF11 | P52732 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290383 | 0.90 | KMT2A (0.87) | KMT2AMEN1ATML3MBTL1RAB9A | |
| SCHEMBL8290627 | 0.88 | KMT2A (1.00) | KMT2AMEN1ATML3MBTL1RAB9A | |
| SCHEMBL13561194 | 0.85 | KMT2A (0.74) | KMT2AMEN1ATML3MBTL1RAB9A | |
| SCHEMBL3128198 | 0.83 | FLT3 (1.00) | KMT2AMEN1RAB9ANPC1FLT3 | |
| SCHEMBL3916274 | 0.83 | KMT2A (0.97) | KMT2AMEN1L3MBTL1RAB9ANPC1 | |
| SCHEMBL7887075 | 0.83 | KMT2A (0.70) | KMT2AMEN1ATML3MBTL1RAB9A | |
| SCHEMBL8289672 | 0.82 | FLT3 (0.97) | KMT2AMEN1RAB9ANPC1FLT3 | |
| SCHEMBL8206445 | 0.82 | TP53 (0.80) | KMT2AMEN1RAB9ANPC1FLT3 | |
| SCHEMBL919352 | 0.82 | MEN1 (1.00) | KMT2AMEN1L3MBTL1RAB9ANPC1 | |
| SCHEMBL5453337 | 0.81 | RAB9A (1.00) | KMT2AMEN1RAB9ANPC1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |