Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 7/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667355 | 0.84 | RYR2 (0.54) | RYR2NOTUMHSD17B3KCNH2HRH3 | |
| SCHEMBL2533362 | 0.76 | NOTUM (0.64) | NOTUMKCNH2HRH3HSP90AA1HSP90AB1 | |
| SCHEMBL29758685 | 0.76 | NOTUM (0.64) | NOTUMKCNH2HRH3HSP90AA1HSP90AB1 | |
| SCHEMBL6867029 | 0.75 | RYR2 (1.00) | RYR2NOTUMKCNH2 | |
| SCHEMBL3081414 | 0.72 | RYR2 (0.43) | RYR2NOTUMHSD17B3KMT2A | |
| SCHEMBL6866477 | 0.71 | RYR2 (0.72) | RYR2NOTUMKCNH2 | |
| SCHEMBL9635059 | 0.71 | RYR2 (0.72) | RYR2NOTUMKCNH2 | |
| SCHEMBL7560987 | 0.71 | RYR2 (0.72) | RYR2NOTUMHSD17B3KCNH2 | |
| SCHEMBL30513187 | 0.70 | NPC1 (0.44) | RYR2MEN1MAPTKMT2ANPC1 | |
| SCHEMBL13622149 | 0.70 | RYR2 (0.71) | RYR2KCNH2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| CN-102695710-B | Tricyclic pyrazole sulfonamide derivatives | MERCK SERONO S.A. (CH) | 2015-08-19 | — | — | CN | disclosed |
| US-9073940-B2 | Tricyclic pyrazol amine derivatives | MERCK SERONO SA (CH) | 2015-07-07 | — | — | US | disclosed |
| CN-102695710-A | Tricyclic pyrazol amine derivatives | MERCK SERONO SA | 2012-09-26 | — | — | CN | disclosed |
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| EP-2499146-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | Merck Serono S.A. (CH) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |
| US-4529725-A | 1-Pyridine substituted quino-benzothiazine | ABBOTT LABORATORIES (US) | 1985-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238545-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | PI4KB, MTOR, PI4KA | RYR2 4407/4885NOTUM 3606/4885HSD17B3 1424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.