Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RYR2 | Q92736 | 7/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8289 | 0.84 | RYR2 (0.59) | RYR2NOTUMHSD17B3KCNH2HRH3 | |
| SCHEMBL6866477 | 0.83 | RYR2 (0.72) | RYR2NOTUMKCNH2 | |
| SCHEMBL29728593 | 0.77 | NOTUM (0.61) | NOTUMTMPRSS2HTR1AADRA2ACYP2D6 | |
| SCHEMBL3704956 | 0.77 | NOTUM (0.61) | NOTUMTMPRSS2HTR1AADRA2ACYP2D6 | |
| SCHEMBL6866534 | 0.74 | RYR2 (0.78) | RYR2NOTUMKCNH2 | |
| SCHEMBL3027013 | 0.72 | RYR2 (0.41) | RYR2ALDH1A1GAAHSD17B3 | |
| SCHEMBL9705347 | 0.72 | NOTUM (0.50) | NOTUMALDH1A1TMPRSS2HTR1AADRA2A | |
| SCHEMBL3081414 | 0.71 | RYR2 (0.43) | RYR2NOTUMALDH1A1ACHEHSD17B3 | |
| SCHEMBL7413427 | 0.70 | RYR2 (0.67) | RYR2NOTUMKCNH2 | |
| SCHEMBL7560987 | 0.70 | RYR2 (0.72) | RYR2NOTUMHSD17B3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004019933-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019933-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |
| EP-0077603-B1 | PROCESS AND INTERMEDIATES FOR PRODUCTION OF BENZOTHIAZINE CARBOXAMIDES | PFIZER INC. (US) | 1986-01-02 | — | — | EP | disclosed |
| US-4536573-A | REACTING BENZOTHIAZINE ESTER WITH HETEROCYCLE AMINE | PFIZER INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4469866-A | ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1984-09-04 | — | — | US | disclosed |
| EP-0077603-A1 | Process and intermediates for production of benzothiazine carboxamides | PFIZER INC. (US) | 1983-04-27 | — | — | EP | disclosed |