Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 18/20 | 0.82 |
| ▸ | HTR3A | P46098 | 16/20 | 0.82 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29397319 | 1.00 | HTR4 (0.82) | HTR4HTR3APARP1PARP2 | |
| Formic Acid Methyl Ester SCHEMBL28074652 | 0.94 | HTR4 (0.77) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL828936 | 0.92 | HTR4 (0.68) | HTR4HTR3APARP1 | |
| SCHEMBL29397140 | 0.92 | HTR4 (0.68) | HTR4HTR3APARP1 | |
| SCHEMBL27850731 | 0.91 | HTR4 (0.82) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL1724211 | 0.90 | HTR4 (0.87) | HTR4HTR3APARP1PARP2 | |
| Felcisetrag SCHEMBL390795 | 0.89 | HTR4 (1.00) | HTR4HTR3A | |
| SCHEMBL828848 | 0.89 | HTR4 (1.00) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL29400324 | 0.89 | HTR4 (1.00) | HTR4HTR3APARP1PARP2 | |
| SCHEMBL1726589 | 0.88 | HTR4 (0.80) | HTR4HTR3APARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143279-B2 | Benzimidazole-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE, INC. (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1899324-B1 | Benzimidazole-carboxamide compounds as 5-HT4 receptor agonists | THERAVANCE INC (US) | 2011-11-30 | — | — | EP | disclosed |